25ml Trilocur for Dogs (trilostane oral suspension) is a prescription-only medicine used to help manage hyperadrenocorticism, commonly called Cushing’s disease. It is intended for dogs diagnosed by a veterinary surgeon and supplied as an oral liquid that can be measured accurately to match the prescribed dose.
Trilocur contains trilostane. 25ml Trilocur reduces the production of steroid hormones made by the adrenal glands, particularly cortisol. In dogs with Cushing’s disease, cortisol levels are higher than the body needs. Excess cortisol disrupts normal metabolism and immune function and can affect many organs over time. By lowering cortisol production, trilostane can help control clinical signs and improve day-to-day comfort.
How Trilocur works
The adrenal glands sit close to the kidneys and produce several important hormones, including cortisol. Cortisol helps the body respond to stress, regulates the use of fat, protein and carbohydrates, supports blood pressure, and influences the immune system. In Cushing’s disease, cortisol is produced in excess, either because the pituitary gland is stimulating the adrenals too strongly or because an adrenal tumour is producing hormones directly.
Trilocur blocks an enzyme involved in the adrenal gland’s steroid production pathway (3β-hydroxysteroid dehydrogenase). This reduces the synthesis of cortisol and related adrenal steroids. The aim of treatment is not to remove cortisol completely, but to bring production back into a controlled range. Because dogs respond differently, dosing and monitoring are important, especially early on and after any dose changes.
Trilocur may be prescribed for:
- Pituitary-dependent hyperadrenocorticism (the most common form), where a pituitary change increases ACTH stimulation of the adrenal glands.
- Adrenal-dependent hyperadrenocorticism, where an adrenal tumour produces excess hormones.