
Epiphen Tablets 60mg - per Tablet
39822
60mg Epiphen is a prescription medication used to treat epilepsy in dogs. Each tablet contains 60mg of phenobarbital, a barbiturate that helps control seizures by stabilising electrical activity in the brain.
ORIGINAL VET PRESCRIPTION MUST BE POSTED TO US AS EPIPHEN IS A CONTROLLED DRUG
Epilepsy is a common neurological disorder in dogs that causes recurrent seizures. Epiphen is often prescribed as a long-term treatment to reduce the frequency and severity of seizures. It is widely used as a first-line antiepileptic drug and requires ongoing veterinary monitoring to ensure safe and effective management of the condition.
How Epiphen Works
Epiphen contains phenobarbital, a medication that works by depressing excessive brain activity to prevent seizures. Seizures occur when there is uncontrolled electrical activity in the brain, leading to sudden and unpredictable episodes of convulsions, twitching, or loss of consciousness.
Phenobarbital works by:
- Increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces nerve excitability.
- Decreasing nerve impulses that cause seizures.
- Stabilising brain activity to prevent sudden electrical surges.
Epiphen is absorbed into the bloodstream after administration and reaches therapeutic levels within a few hours. However, it may take several weeks for the full effects to be observed as the body adjusts to the medication.
Product Features
- Pack Size: - Sold Individually
- Target Animal: - Dog (Canine)
- Related Condition: - Epiphen is an antiepileptic, for use in the control of epilepsy in dogs
- Pet Prescription Required?: - Yes
- Active Ingredient: - Phenobarbital
- Product Name: - Epiphen Tablets 60mg - per Tablet
More Information
Description
60mg Epiphen Tablets for Dogs
Epiphen may only be supplied with a valid veterinary prescription issued by your vet. You should only purchase Epiphen if you have or are in the process of arranging such a prescription. See information bar for further details.
As this medication is a controlled drug we require that the ORIGINAL prescription is sent to us at: Vetmeds Ltd. Unit 2 Airfield Road Trading Estate, Airfield Road, Podington, Northamptonshire NN29 7XA.
Understanding Epilepsy in Dogs
Epilepsy is a neurological condition that causes repeated seizures. It is one of the most common chronic disorders in dogs and can significantly impact their quality of life.
Seizures occur when there is abnormal electrical activity in the brain, leading to sudden, uncontrolled movements and changes in behaviour. Some seizures are mild, while others can be severe and prolonged.
There are two main types of epilepsy in dogs:
- Idiopathic epilepsy – The most common form, with no identifiable cause. It is believed to be hereditary in some breeds.
- Symptomatic epilepsy – Caused by underlying conditions such as brain tumours, head trauma, infections, or metabolic disorders.
Dogs with epilepsy require long-term management with medication to reduce the risk and severity of seizures.
Signs of Epilepsy in Dogs
Seizures can vary in intensity and duration. Some common signs of an epileptic episode include:
- Loss of consciousness – Some dogs may collapse and become unresponsive.
- Muscle twitching or convulsions – Uncontrolled movements, often involving the legs.
- Stiffening of the body – Some dogs may become rigid before the seizure starts.
- Drooling or foaming at the mouth – Increased saliva production during a seizure.
- Unusual vocalisations – Whining, barking, or howling.
- Loss of bladder or bowel control – Some dogs may involuntarily urinate or defecate.
- Disorientation after the seizure – Many dogs appear confused, restless, or lethargic after an episode (postictal phase).
Some dogs experience warning signs before a seizure, such as restlessness, pacing, or seeking attention. These are known as aura symptoms.
Causes and Risk Factors of Epilepsy in Dogs
Epilepsy can develop for different reasons. In idiopathic epilepsy, genetics play a significant role, and certain breeds are more prone to the condition. Some of the breeds at higher risk include:
- Labrador Retrievers
- Golden Retrievers
- Border Collies
- German Shepherds
- Beagles
- Irish Setters
Other possible causes of epilepsy include:
- Brain injuries or trauma
- Brain tumours or infections
- Liver or kidney disease
- Exposure to toxins
- Low blood sugar levels (hypoglycaemia)
Early diagnosis and treatment can help manage epilepsy effectively and prevent severe complications.
Administering Epiphen to Dogs
Epiphen 60mg tablets are given orally, with the dosage prescribed by a veterinarian based on the dog’s weight, seizure history, and overall health.
The medication is usually administered twice daily, at the same time each day, to maintain stable blood levels. Tablets can be given with or without food, but it is important to follow the veterinarian’s instructions precisely.
Epiphen requires regular blood tests to monitor phenobarbital levels and ensure the correct dosage is maintained. Adjustments may be needed depending on how the dog responds to treatment.
If a dose is missed, it should be given as soon as possible, unless it is close to the next scheduled dose. Double dosing should be avoided.
Expected Response to Treatment
Most dogs respond well to Epiphen, with a noticeable reduction in seizure frequency within a few weeks. Some dogs may continue to experience occasional seizures, but they are typically less severe.
It is important to continue treatment consistently, as stopping Epiphen suddenly can cause withdrawal seizures. Any changes to the dosage or treatment plan should only be made under veterinary supervision.
Possible Side Effects of Epiphen
Epiphen is generally well tolerated, but some dogs may experience side effects, especially when first starting treatment. Common side effects include:
- Increased thirst and urination
- Increased appetite
- Mild sedation or drowsiness
- Temporary loss of coordination (ataxia)
These effects usually improve as the dog adjusts to the medication. However, long-term use may require regular blood tests to check for potential liver damage or changes in blood chemistry.
Serious side effects, though rare, may include:
- Jaundice (yellowing of the gums or eyes)
- Severe lethargy or weakness
- Vomiting or diarrhoea
- Behavioural changes, such as increased aggression
If any of these symptoms occur, veterinary advice should be sought immediately.
Precautions and Contraindications
Epiphen should only be used under veterinary supervision and is not suitable for all dogs. Some precautions include:
- Not recommended for dogs with severe liver disease – Phenobarbital is metabolised in the liver, so regular monitoring is essential.
- Use with caution in pregnant or lactating dogs – Veterinary consultation is required to assess the risks.
- May interact with other medications – Phenobarbital can affect the metabolism of other drugs, including steroids and antibiotics.
Regular check-ups and blood tests help ensure the medication remains safe and effective for long-term use.
Storage and Handling of Epiphen
Epiphen 60mg tablets should be stored in a cool, dry place away from direct sunlight. The medication should be kept out of reach of children and other pets.
Unused or expired tablets should be disposed of safely, following veterinary or pharmacy guidance.
Legal category
Epiphen is a POM-V CD(Sch 3) - Controlled Drug - Schedule 3 (Pet Prescription Required)
You may also like

Epiphen Tablets 30mg - per Tablet
30mg Epiphen Tablets are an antiepileptic for use in the control of epilepsy in dogs.
ORIGINAL VET PRESCRIPTION MUST BE POSTED TO US AS EPIPHEN IS A CONTROLLED DRUG

Epitaur 500 - Pot of 90 Capsules
Epitaur Capsules for Dogs are dietary supplement specifically designed to support dogs suffering from epilepsy and other neurological conditions. Epitaur contains a blend of essential nutrients that are often found to be deficient in pets with epilepsy, providing a holistic approach to managing epilepsy in Dogs.
Epitaur Capsules contain a balanced mix of L-Taurine, L-Tyrosine, B-vitamins, Zinc Gluconate, Magnesium Stearate, and Dicalcium Phosphate. L-Taurine, in particular, offers neuroprotective properties and aiding in the overall brain function of dogs. It is especially beneficial in cases of epilepsy, helping to mitigate seizures and improve the quality of life for affected pets.
L-Taurine is an amino acid that is critical for the proper functioning of the central nervous system. For dogs with epilepsy, Taurine acts as a stabilising agent, helping to reduce the frequency and severity of seizures. Additionally, its antioxidant properties protect brain cells from damage and support healthy brain activity.
Pot of 90 Epitaur Capsules

Epitaur Capsules Large Breed - Pack of 180
Epitaur Large Breed is specifically formulated to provide optimum levels of specific deficient nutrients that are normally associated in epilepsy. High conscentrations of taurine are found in the central nervous system, taurine is an essential building block for all other amino acids.
Taurine has a protective effect on the brain, particulary if the brain is dehydrated. In the nutritional world taurine is used in cases of anxiety, epilepsy, hyperactivity, poor brain function and most importantly seizures - Pack of 180 Capsules

Epilease Capsules 250mg - Pack of 60
250mg Epilease capsules are designed to help control seizures in dogs diagnosed with epilepsy. The capsules contain potassium bromide, an active ingredient that stabilises electrical activity in the brain and reduces seizure frequency. Epilepsy is a neurological condition that causes recurring seizures, which can vary in severity and duration.
Seizures occur when abnormal electrical impulses in the brain trigger involuntary movements, loss of consciousness, or behavioural changes. Epilease helps to regulate these electrical signals, reducing the likelihood of sudden seizures and providing long-term management of the condition.
Dogs with epilepsy require consistent medication to maintain stable brain function and prevent seizure episodes. Regular veterinary supervision and monitoring are essential to ensuring the effectiveness of treatment and adjusting dosage if necessary.
How 250mg Epilease Capsules Work
Epilease contains potassium bromide, which works by altering the way nerve cells in the brain transmit signals. Potassium bromide affects chloride channels in neurons, making them less excitable and reducing the risk of spontaneous electrical activity that leads to seizures. This stabilising effect helps to control epilepsy and prevent unpredictable episodes.
Potassium bromide is often used in cases where standard anti-seizure medications, such as phenobarbital, are not effective or cause side effects. It can be used as a primary treatment or in combination with other medications to improve seizure control.
As a long-term treatment, Epilease gradually builds up in the dog's system, requiring consistent daily administration. It may take several weeks before full effects are observed, and close monitoring is necessary to adjust dosage based on the dog’s response.
VETERINARY PRESCRIPTION REQUIRED