Buy Prascend for Horses from UK - 1mg Prascend (Pergolide)
Prascend Tablets contain 1mg Pergolide. Prascend is used as a treatment for Cushing’s disease in horses. A small benign tumour in the pituitary gland causes an increased release of cortisol from the adrenal glands causing equine Cushing’s syndrome. Treatment with Prascend improves the quality of life of Cushing’s-affected horses by managing clinical signs and decreasing the risk of complications of PPID, including those that have potential to be life threatening.
Prascend tablets may be administered orally by dissolving the tablet with a small amount of water and/or mixing with molasses or other sweetener; taking care to rinse the dosing apparatus with water to ensure entire dose of Prascend is administered; use immediately. Most horses respond to Prascend therapy and are stabilised at an average dose of 2 µg/kg.
Prascend is NOT suitable for use in Horses intended for human consumption.
Prascend is a synthetic ergot derivative and is a potent dopamine receptor agonist. As with other dopamine agonists, Prascend inhibits the release of prolactin. In horses with PPID, Prascend is believed to exert its therapeutic effect by stimulating dopamine receptors, and has been shown to decrease the plasma levels of adrenocorticotropic hormone (ACTH), melanocyte stimulating hormone (MSH), and other pro-opiomelanocortin peptides.
Prascend tablets may be administered orally by dissolving the tablet with a small amount of water and/or mixing with molasses or other sweetener; taking care to rinse the dosing apparatus with water to ensure entire dose of Prascend is administered; use immediately. Most horses respond to Prascend therapy and are stabilised at an average dose of 2 µg/kg.
Normally it takes 6 to 8 weeks until clinical signs improve. Improvement of clinical signs is not necessarily correlated to an improvement of endocrinologic test results. The earliest signs are improvement in the overall attitude and behavior of the horse (e.g. horses become more active) is usually observed within 30 to 60 days of treatment institution.
What is the difference between Pergolide and Prascend?
Pergolide is the active ingredient in Prascend Tablets. Each Prascend tablet contains 1mg of Pergolide. Prascend is the licensed Equine version of Pergolide that has undergone rigorous testing before being approved by the Veterinary Medicines Directorate for use in Horses.
Unlike generic Pergolide, VMD approval gives Veterinary Surgeons and horse owners the peace of mind that Prascend is manufactured under consistent conditions and tested to the same standards as human drugs. Strict manufacturing guidelines ensure the product is pure and consistent and potency is stable up to the validated expiration date.
Prascend is considered the gold standard for treatment of PPID. Pergolide, a dopamine agonist, acts to restore the inhibition to the pars intermedia, downregulating the activity of this area, thereby decreasing the production of hormones like ACTH.
Prascend tablets are used to control equine Cushing’s disease (also referred to as hyperadrenocorticism). Equine Cushing’s Disease (also known as PPID) is one of the most common problems affecting the endocrine (hormonal) system of horses and ponies. Cushings disease in horses can cause many symptoms. Classically horses become more hairy and require more clipping than usual. Affected horses often develop a pot-bellied type appearance and can develop fat pads around the face and eyes in particular. Cushingoid horses are also more prone to lameness, laminitis is a particular problem.
Other symptoms include an increased thirst and appetite, increased urination and increased infections. For example, wounds may take longer to heal than would be expected. Clinical improvement with Prascend is expected within 6 to 12 weeks. Some horses may respond clinically at lower or varying doses, and it is recommended to titrate to the lowest effective dose per individual based on response to therapy, whether it is effectiveness or signs of intolerance. A small number of horses may require doses as high as 10 µg/kg per day. In these rare situations, appropriate additional monitoring should be implemented.
Where can I buy Prascend from?
in the UK, Prascend may only be legally obtained from a licensed Vet or Pharmacist after your Vet has decided it is a suitable treatment for your Horse. Since the law changed in 2005, you are able to purchase veterinary medicines from a registered dispensary using a written prescription given to you by your Vet.
However, you can purchase Prascend without a prescription from us if it is to be sent to a country other than the UK. All we require is confirmation by email that you horse has been diagnosed with Cushing's disease and is currently being treated with Prascend under Veterinary supervision and that you are aware of the correct dose to give and will read and obey the included datasheet.
VetDispense operates from a fully legal practice premises in Northamptonshire that is registered with the Royal College of Veterinary Surgeons and is open to inspection by the Veterinary Medicines Directorate. The Prascend dispensed by VetDispense is exactly the same as that given to you at your own vets but is often available at a much lower cost.
Simply obtain a prescription from your Vet and use it to place an order at VetDispense. We can also send Prascend to other countries using tracked airmail – please contact us for details.